HIV

Our nanoDDI platform is designed to deliver long-acting HIV prevention without the daily pill

Powering consistency in HIV prevention

The nanoDDI is a subcutaneous nanofluidic implant designed to deliver PrEP therapy continuously over extended periods without daily dosing.

Placed beneath the skin in a minimally invasive procedure, the implant uses a precision silicon nanofluidic membrane to maintain plasma levels above the threshold required for efficacy. Because the platform is long-acting and refillable, it is designed to support uninterrupted protection over time.

This approach is designed to:
lower total drug exposure
avoid the peaks and troughs associated with daily dosing
improve convenience and adherence
support durable protection without repeated dosing interruptions

the nanoDDI

Encouraging preclinical evidence

Preclinical studies demonstrate that nanoDDI can provide long-acting systemic delivery in HIV prevention models.1234

Current trial Phase:
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
Commercial
Key findings include:
sustained systemic drug delivery over extended periods
efficacy demonstrated in HIV PrEP studies in non-human primates
compared with systemic therapy, nanoDDI-facilitated drug delivery achieved protection with lower overall drug exposure
uninterrupted delivery potential extending beyond two years

Together, these findings suggest that nanofluidic implant-based delivery may support durable HIV prevention while reducing the burden of daily oral therapy.

Why HIV prevention still needs better delivery

Pre-exposure prophylaxis (PrEP) is highly effective, but its protection depends on consistency. For many people, taking a daily pill over months or years can be difficult to sustain. Missed doses may reduce protection, while treatment fatigue, anxiety, and cumulative drug exposure can add to the burden over time.

Long-acting delivery creates the potential to reduce that burden by shifting HIV prevention away from daily adherence and toward more consistent exposure over time.

A new era in long-acting prevention

Our nanoDDI represents more than an alternative to daily oral PrEP. By combining long duration, lower drug exposure, and refillability, it points toward a new model for HIV prevention, one designed to reduce daily burden while supporting more consistent protection over time.

Get in touch about what long-acting, drug-agnostic delivery could make possible.

Connect with us